ABSTRACT
OBJECTIVES: The aim of the study is to report a series of 17 cases of ankle bi-arthritis that occurred shortly after Covid-19 RNA vaccination, and to discuss the potential role of these vaccines in the pathogenesis of this rheumatological manifestation. METHODS: All patients were examined in the same department and received a full work-up to investigate the usual causes of ankle bi-arthritis. No rheumatic inflammatory disease occurred after 9 months follow -up. A post vaccination serological follow-up in search of anti-Spike antibodies was request for all patients. RESULTS: All patients recovered with low dose of prednisolone within <2 months, except one who could not be weaned off corticosteroids. The level of antibodies found was very high in all patients. CONCLUSION: The ankle bi-arthritis occurrence chronology, the follow-up, and the similar clinical presentation might suggest a pathogenic role of RNA vaccination.